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Vesugen is a bioregulator and geroprotective tripeptide. Research has shown it to protect the vascular system from the effects of aging by limiting the development of atherosclerosis and decreasing overall endothelial cell dysfunction. Systems that are sensitive to vascular damage and decline therefore show the most obvious effects from Vesugen administration. These systems include the central nervous system and cardiovascular system. Vesugen appears to play a prominent role in regulating sirtuin 1 protein levels. Sirtuin 1 has important effects on metabolic processes and helps to reduce the effects of aging. Sirtuin 1 is activated as a result of calorie restriction and is therefore thought to be one of the proteins responsible for the profound anti-aging effects associated with calorie restriction.